Osteogenesis imperfecta is caused by a deficiency of which substance?

• A. Calcium
• B. Collagen
• C. Vitamin D
• D. Magnesium

Answer: (B)

Osteogenesis imperfecta, often referred to as "brittle bone disease," is primarily caused by a deficiency in collagen, a crucial protein that provides structure and strength to bones and connective tissues. In osteogenesis imperfecta, the body produces defective collagen or insufficient amounts, which leads to the formation of weak and fragile bones that are prone to fractures, even with minimal trauma. There are different types of osteogenesis imperfecta, each linked to varying genetic mutations that affect collagen synthesis or structure.

Collagen is vital in the composition of bone matrix, and without sufficient collagen, bones cannot maintain their normal strength and integrity. This condition highlights the importance of collagen not only in bone health but also in overall connective tissue function throughout the body. Understanding the role of collagen helps clarify why its deficiency leads directly to the symptoms observed in osteogenesis imperfecta.